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| Veiga,C.P.; Miczek,K.A.; Lucion,A.B.; Almeida,R.M.M. de. |
| Serotonin (5-HT1B) receptors play an essential role in the inhibition of aggressive behavior in rodents. CP-94,253, a 5-HT1B receptor agonist, can reduce aggression in male mice when administered directly into the ventro-orbitofrontal (VO) prefrontal cortex (PFC). The objective of the current study was to assess the effects of two selective 5-HT1B receptor agonists (CP-94,253 and CP-93,129), microinjected into the VO PFC, on maternal aggressive behavior after social instigation in rats. CP-94,253 (0.56 µg/0.2 µL, N = 8, and 1.0 µg/0.2 µL, N = 8) or CP-93,129 (1.0 µg/0.2 µL, N = 9) was microinjected into the VO PFC of Wistar rats on the 9th day postpartum and 15 min thereafter the aggressive behavior by the resident female against a male intruder was... |
| Tipo: Info:eu-repo/semantics/other |
Palavras-chave: Prefrontal cortex; 5-HT receptors; Serotonin; Maternal behavior; Aggression. |
| Ano: 2007 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2007000600012 |
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| Guimarães,R.M.; Schaufelberger,M.S.; Santos,L.C.; Duran,F.L.S.; Menezes,P.R.; Scazufca,M.; Gouvea,M.T.V; Busatto,G.F.. |
| Previous cross-sectional magnetic resonance imaging (MRI) studies of healthy aging in young adults have indicated the presence of significant inverse correlations between age and gray matter volumes, although not homogeneously across all brain regions. However, such cross-sectional studies have important limitations and there is a scarcity of detailed longitudinal MRI studies with repeated measures obtained in the same individuals in order to investigate regional gray matter changes during short periods of time in non-elderly healthy adults. In the present study, 52 healthy young adults aged 18 to 50 years (27 males and 25 females) were followed with repeated MRI acquisitions over approximately 15 months. Gray matter volumes were compared between the two... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Gray matter; Aging; Voxel-based morphometry; Magnetic resonance imaging; Prefrontal cortex; Hippocampus. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000600007 |
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| Jalili,C; Salahshoor,M. R; Khademi,F; Jalili,P; Roshankhah,S. H. |
| Nicotine is the most important alkaloid compound in tobacco. One of the major effects of nicotine is stimulation of mesocorticolimbic system. Prefrontal cortex plays a pivotal role in personality and mental state. It is considered the main cause of addiction as it is located in mesocorticolimbic dopamine system. Twenty four male rats were divided into four groups based on nicotine administration dose (0, 0.5, 1 and 1.5 g/kg). After animals were anesthetized, their brains were fixed using transcardiac method. Tissue processing and Golgi staining were performed and the stained tissue sections were analyzed by optic microscope and Motic software. By increasing the dose, nicotine significantly decreased the number of neuronal processes. In the higher dose,... |
| Tipo: Journal article |
Palavras-chave: Morphometric; Prefrontal cortex; Nicotine; Rat. |
| Ano: 2014 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022014000300003 |
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| Herman,J.P.; McKlveen,J.M.; Solomon,M.B.; Carvalho-Netto,E.; Myers,B.. |
| The mammalian stress response is an integrated physiological and psychological reaction to real or perceived adversity. Glucocorticoids are an important component of this response, acting to redistribute energy resources to both optimize survival in the face of challenge and to restore homeostasis after the immediate challenge has subsided. Release of glucocorticoids is mediated by the hypothalamo-pituitary-adrenal (HPA) axis, driven by a neural signal originating in the paraventricular nucleus (PVN). Stress levels of glucocorticoids bind to glucocorticoid receptors in multiple body compartments, including the brain, and consequently have wide-reaching actions. For this reason, glucocorticoids serve a vital function in negative feedback inhibition of their... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Hypothalamo-pituitary-adrenocortical axis; Corticotropin-releasing hormone; Glucocorticoid receptor; Amygdala; Hippocampus; Prefrontal cortex. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000400002 |
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| Negrón-Oyarzo,Ignacio; Lara-Vásquez,Ariel; Palacios-García,Ismael; Fuentealba,Pablo; Aboitiz,Francisco. |
| Schizophrenia is a severe psychiatric disorder that results in a significant disability for the patient. The disorder is characterized by impairment of the adaptive orchestration of actions, a cognitive function that is mainly dependent on the prefrontal cortex. This behavioral deficit, together with cellular and neurophysiological alterations in the prefrontal cortex, as well as reduced density of GABAergic cells and aberrant oscillatory activity, all indicate structural and functional deficits of the prefrontal cortex in schizophrenia. Among the several risk factors for the development of schizophrenia, stress during the prenatal period has been identified as crucial. Thus, it is proposed that prenatal stress induces neurodevelopmental alterations in the... |
| Tipo: Journal article |
Palavras-chave: Schizophrenia; Prefrontal cortex; Prenatal stress; Functional connectivity; DNA methylation; Reelin. |
| Ano: 2016 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602016000100016 |
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